Comparison of the effects of high-intensity interval training and moderate-intensity continuous training on indices of liver and muscle tissue in high-fat diet-induced male rats with non-alcoholic fatty liver disease

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic diseases. It shown that moderate to high physical activities can play a crucial role in improving this disease. Aim The purpose study was explore effects high-intensity interval training (HIIT) and moderate-intensity continuous (MICT) on levels myonectin serum tissue acid transport protein 4 (FATP4) male rats with NAFLD. Materials methods Thirty-three were randomly divided into five groups: high-fat diet confirm NAFLD induction ( n = 5), normal sedentary 7), HIIT MCIT 7). Induction performed by feeding for 12 weeks containing 60% fat. protocols sessions per week 8 weeks. group has × min running treadmill up 80–95% maximal oxygen uptake (VO2max) then recovered at 50–60% VO2max. MICT protocol VO2max 50 min. FATP4 also measured animal Elisa kit (Zellbio, Germany) sensitivity 0.02 ng/L. Insulin resistance evaluated insulin homeostasis assessment index using following formula (HOMA-IR): “fasting glucose (mg/dl) fasting (mg/L) ÷ 405”. One-way ANOVA analysis variance utilized statistical analyses Tukey’s post hoc test significant level p < 0.05. Results 8-week intervention showed both positively influenced 0.05). Moreover, there difference between trained groups Conclusions Altogether, lead valuable adaptations recovery rats.